The latest research progress in the preparation and application of cellulose derivative carboxymethylcellulose (CMC)-based food packaging films in recent years are reviewed, with the focus on the preparation methods of CMC-based films, as well as the summarization on the application of CMC materials in traditional edible fresh-keeping packaging films and green intelligent indicator films etc.. The preparation, popularization and application of CMC-based food packaging films is of great significance in reducing the use of petroleum-based non-degradable plastic bags and white pollution, while improving food quality and safety, which has important social significance and economic value.