Heterogeneous Fenton technology is an effective method to degrade organic pollutants in water. Compared with the classical Fenton reaction, the heterogeneous Fenton reaction had the advantages of recyclable, wide pH response range, no iron sludge, and easy solid-liquid separation. However, the heterogeneous Fenton catalytic system had the bottleneck of low activity under neutral conditions, poor catalyst stability and low hydrogen peroxide utilization rate. In order to solve the above bottlenecks, excellent heterogeneous Fenton catalysts were coupled with multiple active centers and co-synergism with multiple technologies to enhance catalytic activity. In order to further expand the application of Fenton technology, the study of Fenton reaction needs to be carried out from several aspects: improving the pH application range, enhancing the catalytic activity and stability, and developing heterogeneous Fenton catalysts with low cost and high degradation efficiency.