In order to verify the safety of antioxidant active plastic bottle caps and the feasibility of using mathematical simulation to replace migration tests, the antioxidant active caps were prepared by adding butyl hydroxyanisole (BHA) and butylated hydroxytoluene (BHT) to high-density polyethylene (HDPE). The initial content of antioxidants in HDPE antioxidative bottle caps was detected by HPLC. The migration of BHA and BHT from the caps into food simulants 50% ethanol and 95% ethanol was determined. In addition, AKTS-SML software was used to simulate the migration with the diffusion coefficient of Piringer model and Brandsch model respectively under the migration conditions of 70 ℃/2 h and 40 ℃/10 d. The results showed that the recovery rate of the detection method was 78.8%~111.0%, and the relative standard deviation was in the range of 0.1%~4.0%. The actual migration amount of BHA and BHT in the bottle cap was less than the simulated migration amount. The concentration of antioxidant, migration time, molecular weight and the polarity of the simulated liquid all had a great influence on the migration results. The feasibility of using mathematical simulation to replace the migration experiment in the safety assessment of the antioxidant active bottle caps remained to be improved.