TiO2 sol was prepared by sol-gel method and supported on the surface of silica-alumina ceramic mesoporous spheres for the adsorption and photocatalytic degradation of methyl orange solution. The apparent morphology, crystal structure, adsorption and photocatalytic properties of the samples were characterized and detected by environmental scanning electron microscopy, X-ray diffractometer, Fourier transform infrared spectrometer and visible spectrophotometer. The results showed that the TiO2 was coated on the surface of silica-alumina ceramic mesoporous spheres with high roughness coating and the TiO2 was anatase crystal. In the dark condition, silica-alumina ceramic mesoporous spheres and TiO2-supported silica-alumina ceramic mesoporous spheres only had adsorption effect on methyl orange, with similar adsorption performance. However, under ultraviolet light condition, TiO2 supported silica alumina ceramic mesoporous spheres not only had adsorption effect on methyl orange, but also showed good photocatalytic degradation activity.