N-tallow-1, 3-propylenediamine sodium chloroacetate (N-EDSC) was prepared, and the optimal conditions for synthesis of N-EDSC were studied through single factor experiment and orthogonal experiment. The optimum conditions were n(SD) : n(N-ED)=1:1, the amount of catalyst of 2.5%, the reaction temperature of 70 ℃, and the reaction time of 15 h. Analysis of the structure of the target product N-EDSC by infrared spectroscopy showed that the target product was indeed N-EDSC. The surface tension test of the N-EDSC aqueous solution showed that N-EDSC had strong hydrophilicity, which was beneficial to its use in aqueous systems. The dispersibility of N-EDSC in water-based inks was analyzed in terms of absorbance and particle size, and the results showed that the dispersibility was better when the addition of N-EDSC was 1.2% in water-soluble ink.