Antibacterial hydrogels have been playing an important role in modern medicine. The better antibacterial properties have always been the focus of experts and scholars. The research progress of natural antibacterial agents / hydrogels, inorganic antibacterial agents / hydrogels and organic antibacterial agents / hydrogels was reviewed. The dual mode antibacterial MOFs/ hydrogel in the new antibacterial hydrogel would be the focus of future research.