In order to study the application of ultra-high pressure technology in scallop shelling, 200~400 MPa high pressure has been applied to the pretreated scallops for 0~300 seconds. The x-uniform test table with 2 factors and 11 levels was selected to design the test conditions according to the uniform experimental design method. The regression equation of the experimental factors and the total number of colony was established by measuring the meat yield, water holding capacity, TVB-N value and other indicators of scallops. The processing parameters of scallop under ultra-high pressure were optimized by using response surface curve. The optimal processing parameters were determined according to the test pressure and holding time corresponding to the extreme values of each index. According to the calculation results, in the process of ultra-high pressure scallop treatment, with the experimental pressure being 300 MPa and the holding time about 180 seconds, a higher shelling rate and meat yield could be obtained, while a higher nutritional value and storage quality of scallop were maintained as well.