In order to improve production level and efficiency in the era of “Industry 4.0”, the intelligent monitoring and protection system in manufacturing industry is essential. In the packing process of the hazardous powder materials, the protection of static electricity is of great significance. By researching on the numerical relationship between measuring the electrostatic voltage on the outer surface of packaging and the actual electrostatic voltage inside the package, a set of hypothetical model simulating the inside and outside electrification condition of the powder packaging bag was proposed, with a set of electrostatic monitoring model designed. Based on LabVIEW software, a complete set of static voltage detection for packaging process was designed. The test results showed that the system was stable in testing performance and could be used for safety monitoring in the process of hazardous powder material packing.