In view of the problems such as fatigue, pain and stuffiness of auricle when wearing headphone for a long time, the idea of structure design for headphone from the perspective of ergonomics was put forward with a preliminary scheme formed through modeling design. Using ANSYS finite element simulation analysis method, the deficiency of the design scheme was found out, then the feasibility of the optimization scheme was verified after improving the design scheme through optimization design once again. Through the improvement in ergonomics of headphone, users would be provided with satisfactory customized solutions which could be of reference for the design of similar products.