In order to calculate the ink formula more precisely and ensure the consistency of color reproduction based on improving printing speed and printing quality, Pantone297C、Pantone273C、Pantone450C were used as the standard samples in experiment, with the database establishment of CMYK four color printing ink and Saunderson correction of standard sample, base materials and four color printing ink. In Matlab, the single constant color matching model was set up to calculate ink formula and verify the accuracy of ink formulation by comparing the spectral reflectance and color difference of target and matching colors. Experimental results showed that reflectance curves of target and matching colors of Pantone297C, Pantone273C, Pantone450C were basically consistent. For Pantone297C, the color difference of target color and matching color was 1.21, while it was 0.96 for Pantone273C and 2.65 for Pantone450C, which verified the correctness of the four color ink database and the practicability of the single constant spectrum matching algorithm based on Kubellka- Munk.