Oriented to the knowledge structure and ability requirement of packaging engineering talents, mechanics of cushioning packaging materials should be a compulsory major course aimed at improving the talent cultivation plan and the corresponding curriculum system of packaging engineering. The setting necessity, knowledge system and experiment items are analyzed in detail, in view of the talent cultivation requirement and curriculum system consummation. The know-ledge system of this course is subdivided, and the corresponding knowledge points, experiment specifications and contents, and reference books are introduced in detail as well. According to the setting requirements, it is found that the effect is good based on two years of teaching practice. From questionnaire surveys on content novelty, practicality and employer satisfaction degree, it is shown that this course setting is very important and helpful for the college students, in terms of the curriculum system consummation of packaging engineering, engineering ability improvement and employment.