In view of the information revolution wave triggered by big data and new situation of great development of the national cultural industry, the serious challenge and historic opportunity are analyzed for the traditional small and micro enterprises. First, the demerits such as the innovation insufficiency, unreasonable industrial structure, undiversified profit source, poor risk resistance and serious environment pollution generally existing in many printing enterprises are pointed out, with the ways to conforming to the times and keeping up with the trend to accelerate the transition from the traditional processing industry to modern services being discussed. Finally, three upgrading strategies are creatively put forward for small and micro enterprises to realize the transformation and upgrading, which are cultural creative industry integration and cultural connotation enrichment, networking platform fusion, value-added profit exploitation, all media digitalization and development of green on-demand printing.