The plastic packaging materials for medicine commonly include polyethylene, polyvinyl chloride, polystyrene, polypropylene, etc. The performances of these materials have some defects that affect the medicine quality and safety performance. The main influencing factors are: plastic adsorption of drugs, plastics additive migration to the drug, the decomposition of polymer monomer, breathable moisture permeability of the material etc.. In order to reduce negative impacts on drug quality and safety performance due to plastic packaging, the solutions are put forward as choosing medicine packaging materials scientifically, promoting the use of medical environmental protection plasticizer vigorously, carrying out medical plastic packaging market access system, controlling the drug circulation environment security strictly etc..