National medicine brand building requires penetrating the cultural factor into the packaging design. In the deconstruction of the national culture, cultural factors such as ethnic customs, national ethics, ethnic art could be utilized to make the national pharmaceutical products have more cultural and business values by integrating all these cultural factors together. Implantation of cultural factors into packaging design of national medicine includes injection, mosaic, hybrid, compound and so on. Cultural reflection on the product packaging design not only creates conditions for national medicine brand building, but also brings new challenges and opportunities for the packaging design industry.