The bacteriostatic circles of the egg-white lysozyme and tea polyphenols were measured by filter paper dispersion, and the bacteriostasis effect of durability was observed. Using the double dilution method, the individual and combined minimum inhibitory concentration (MIC) of the egg-white lysozyme and tea polyphenols were determined respectively. The joint bacteriostasis effects of them were evaluated by FIC value. Then, the best mixed proportions were ensured. The results show that: the combined application of the egg-white lysozyme and tea polyphenols displayed that they had addition effect for staphylococcus aureus and a strong addition effect for escherichia coli with salmonella.