On the basis of the Fick’s law, the migration model of silver-loaded zeolite antibacterial agent to distilled water, 65% ethanol, 4%(v/v) acetic acid has been built. Result shows that although the migration of antibacterial agent in distilled water can not be accurately reflected by the model, the migration of silver-loaded zeolite in 65% ethanol and 4%(v/v) acetic acid after 240h can be greatly simulated. Meanwhile, the migrations of silver-loaded zeolite in antibacterial kraft paper under different initial mass concentrations, effective diffusion coefficient, thickness of paper and migration time are discussed by the model in order to provide a new way to the safety assessment of antibacterial kraft paper.