Due to the fact chatter seriously restricts the quality and efficiency of milling, and in view of a realization of a high efficiency chatter-free milling process, a milling stability prediction method has thus been proposed by using Rényi entropy as the stability criterion. Firstly, the Runge-Kutta method with variable step sizes is used to solve the milling dynamic differential equation, thus obtaining the time domain signals of vibration displacement and cutting forces; secondly, based on the calculation of Rényi entropy of the simulated time domain signal, the milling stability under the given cutting condition can be determined according to the predefined chatter threshold, followed by a comparison of the stability lobe diagram obtained by simulation with the flutter verification test results, thus verifying the validity of the proposed prediction method.