With the location of express logistics distribution center as the research object, combined with its location characteristics, a construction can be achieved of the objective function containing fixed investment cost, management cost, transportation cost and many other cost elements, thus establishing the location model based on the genetic algorithm, with the improved solution strategy or method to solve the algorithm model, which effectively improves the efficiency and efficiency of the algorithm model. As for the case research part, Matlab 2017A mathematical simulation programming software is combined with the algorithm model to solve the example, which verifies the effectiveness and feasibility of the genetic algorithm model in the study of the location problem.