With a heavy weight to be loaded and under harsh working conditions, the electric wheel dump truck has high requirements for the structural safety of its frame as the main transport bearing structure. In order to study the structural mechanical properties of a certain type of electric wheel dump truck frame, a frame finite element model has thus been established, with a strength analysis to be carried out of the frame structure under different working conditions based on the inertial release method. The results show that the relative error between the simulation results and the test results is within 10%, suggesting that the strength meets the design requirements. In addition, based on this statistics, a modal analysis and frequency response analysis of the frame structure are carried out. Among them, the first-order modal frequency of the frame is 21.3 Hz, and the frequency response frequency of the dangerous point of the frame is 29.0 Hz, without overlapping with the load excitation frequency, thus effectively avoiding the occurrence of resonance.