In order to study the technological innovation efficiency of high-end equipment manufacturing industry in Hunan Province, a static and dynamic research has thus been carried out on the technological innovation efficiency of five subdivision sectors of high-end equipment manufacturing industry in Hunan Province from 2011 to 2016. The static research results show that most of the high-end equipment manufacturing enterprises in Hunan Province are DEA effective, and still some of them are not DEA effective due to their low scale efficiency. The dynamic results show that the total factor productivity of high-end equipment manufacturing industry in Hunan Province is greater than 1 from 2011 to 2016, but the growth rate is relatively slow, with the low technological progress index being the main influencing factor. Therefore, it can be inferred that technological progress plays a major role in the limitation of TFP, an indication that the technical level of Hunan Province needs to be strengthened. Finally, based on the empirical analysis, it is suggested to improve the technological innovation efficiency of equipment manufacturing industry in Hunan Province from three aspects: improvement of the utilization rate of resources with full play given to the advantages of cluster; promotion of the cooperation between scientific research institutes, universities and high-end equipment manufacturing industry in Hunan Province; introduction, assimilation and innovation of key technologies of equipment manufacturing industry of developed countries.