A research has been conducted on the effect of electrophoretic technology on the thickness and adhesion of electrophoretic paint film by using the response surface method. The electrophoretic voltage, time and solid mass fraction have been determined as the key parameters based on experimental analysis. By adopting the central composite experiment method, a three-factor process experiment has thus been designed, followed by a study on the effects of different process combinations on the properties of paint film. Then the film thickness and adhesion can be measured by a minitable analysis, with a P value being less than 0.05 and R2 value more than 98%, thus verifying the validity of the fitting curve, with the functional relationship between each factor and film thickness and adhesion finally obtained. The results show that, with the solid fraction being 21.9%, the voltage 283.4 V and the time 279 s, the film, with a thickness of about 26.45 μm, and an adhesion of about 6.12 MPa, exhibits the best comprehensive performance. Finally, the experiment confirms that the error between the film performance and theoretical value is about 2%, and the stability of the film quality with its optimized comprehensive performance can be verified by the batch production.