In view of the construction requirements of the new-generation intelligent substations, namely “standardized design, industrial processing, modular construction, mechanical construction”, as well as the characteristics of transformer substations, based on an improvements made in its general layout and distribution devices, an optimized design has been proposed for 110 kV intelligent substations in Changning city, followed by a comparison between the proposed design and the conventional scheme. The research results show that the floor space of the optimized transformer substation accounts for only 32% of the conventional one; the building blocks cover an area of 0 m2, which decreases by 551 m2 compared to the conventional scheme. The dynamic total investment of the optimized substation is reduced by 4 349 500 RMB, accounting for 81% of the conventional scheme.