Aiming at the problem of the seam-line in image mosaic, a color transfer algorithm directly in RGB color space is applied to image mosaic technology and to eliminate the seam-line. Firstly, Harris is used to extract feature points and BRISK descriptor is used for binary bitstring description of the points; Then Hamming distance is used to match feature points and RANSAC algorithm to calculate transformation matrix, and the method of gaussian-weighted is used for fusing image; Finally, by means of the color transfer algorithm, adjusts the color of stitching image. Experiments show that the algorithm has a good effect in eliminate image seam-line.