In view of the defect detection of aluminum-plastic blister drug packaging, put forward a matching method based on LBP histogram and SIFT. First, extracted the feature points in the image of aluminum-plastic blister drug packaging, and then calculated the LBP histogram of the surrounding area. Finally matched the feature points to judge if there is defect on the medicine packaging. The test results show that compared to common SIFT algorithm, the method has faster computing speed and meets the demand of industrial production.