Hybrid nanoparticles as catalyst are applied in various industrial fields. However, nano particle fluidization performance is poor, it is needed to study the improving method. At present, the research at home and abroad focuses mostly on fluidization of single nanoparticles by adding coarse particles and the fluidization of mixed nanoparticles in extra force fields, and there is no the report about fluidization of mixed nanoparticles with adding particles. Investigated the fluidization behavior of the mixture of SiO2 and TiO2 nanoparticles by adding 3 kinds of FCC coarse particles, and provided experimental basis for studying the mechanism of crashing, agglomerating and breaking among mixed nanoparticles. Found that the simple hybrid nanoparticles were difficult to be fluidized, and with adding coarse FCC particles, the fluidization behavior were obviously improved. The improving fluidization behavior of hybrid nanoparticles is related to the size and adding amount of FCC particles. In addition the fluidization effect of adding FCC2 and FCC3 coarse particles is better than that of adding FCC1 coarse particles. Under the same amount adding, the fluidization of pure SiO2 is best and the fluidization sequence from good to bad is w(SiO2): w(TiO2)=7:3，w(SiO2): w(TiO2)=5:5, w(SiO2): w(TiO2)=3:7 and pure TiO2 nanoparticles.