For problems of multiple images stitching of certain rotation angle, puts forward an image mosaic optimization algorithm based on SIFT-ACO. After the mosaic image preprocessing, the algorithm uses SIFT algorithm to extract the image features, adds classic intelligent optimization algorithm to image registration and makes image feature points registration, at last fuses multiple images and obtains a wide viewing angle, seamless and high precision image. The experimental result of image mosaic of different angles indicates that the algorithm can improve the accuracy of image matching effectively without affecting the overall visual effect.