Through the fatigue crack growth tests of pure shear rubber specimens, obtained the relationship between the fatigue crack growth rate and the strain energy release rate, and with energy release rate range as damage parameters, built a fatigue crack growth life prediction model of rubber under multiaxial stress state. Based on the finite element analysis software ABAQUS and the corresponding equivalent stress method, obtained the energy release rate range of rubber bushing under fatigue loadings. Predicted the fatigue crack growth life of rubber bushing and verified through fatigue bench test. The results indicate that there is no failure and damage occurring to the rubber bushing after 2 million cycles of fatigue test, and it is coincident with the predicted value.