Aiming at the increasing demand of speed, distance and stability of video signal transmission system, designed and implemented the schemes about the long-distance and high-speed serial data transmission system based on the low voltage differential signal transmission technology, and solved the problems of large power consumption, poor stability and slow data transmission, etc. The system converted PAL analog video signal to RGB565 digital signal and by encoding chip DS90C383, transformed the 16 bits of data, sync signal and enable signal into three channels of differential signal, thereby realized video signal differential transmission.