In view of a supply chain of perishable products with a single manufacturer and a single retailer and under the precondition of two-stage production and twice order, sets up a decision-making model based on option contract with quick response and quantity flexible strategy. Analyses the model properties and verifies the results through an example. The research shows that by means of incorporating option mechanism, quantity flexible strategy and quick respond strategy, not only improves manufacturers and retailers’expected profits but also realizes the supply chain coordination easily.