The biosorption rule for uranium of Saccharomyces cerevisiae has been studied，which shows the 98.6% adsorption efficiency for uranium of saccharomyces cerevisiae has been attained in the case of 10.0mg/L of uranium for concentration quality. The uranium adsorbility is closely in connection with its pH value of which the best rang is from 4.0 to 6.0；and the adsorption pattern of uranium on saccharomyces cerevisiae is consistent with Langmuir and Freundlich isotherm. Comparing with these two, the Freundlich model is better with correlation coefficient of 0.9983. Then resolution efficiency for uranium is 94.2% when it attained with 0.1mol/LNaHCO3.