The influencing factors of 4-tert-Butylphenylboronic acid preparation are analyzed with the Grey Correlation Degree method. The analysis showed the order of influencing factors as follows : reaction temperature＞reaction time＞reactants molar ratio. A optimized process for preparation was thus obtained as follows: the reactants molar ratio of the trimethyl borate to 1-bromo-4-tert-butylbenzene is 1.4:1, the temperature is at -20 ℃, and the reaction time 160 min. The outcome of Mass spectra , nuclear magnetic resonance spectroscopy and infrared spectra superficial characteristics and target outcome structure were consistent.