With the interactive coupling relationship of cultural management and system management as the basis, the basic principle of harmonious management theory as the guiding ideology and the basic operation ways and methods of harmonious management mechanism as supporting tools, an approach to harmonious enterprise management order based on harmonious management theory is explored through analyzing the construction process of enterprise management system of Zhuzhou Qianjin Pharmacy Co., Ltd. and systematically investigating how the company applied high-level evolution with “enterprise culture induction”, how it achieved optimization via “rational system design” and how it increased its efficiency by interacting coupling of management mechanism.